Tropomyosin 1 genetically constrains in vitro hematopoiesis.

Christopher Stephen ThomChintan D JobaliyaKimberly LorenzJean Ann MaguireAlyssa GagnePaul GadueDeborah L FrenchBenjamin Franklin Voight

Published in: BMC biology (2020)

Our findings may help explain human genetic associations and identify a novel genetic strategy to enhance in vitro hematopoiesis. A similar trait-specific gene prioritization strategy could be employed to help streamline functional validation experiments for virtually any human trait.

Keyphrases

genome wide
endothelial cells
copy number
induced pluripotent stem cells
pluripotent stem cells
gene expression
transcription factor