Targeting the Epigenetic Reader ENL Inhibits Super-Enhancer-Driven Oncogenic Transcription and Synergizes with BET Inhibition to Suppress Tumor Progression.

Yongheng Chen Ying Ying Wenlong Ma Hongchao Ma Liang Shi Xuefeng Gao Min Jia Meiqi Li Xiaoman Song Weixiao Kong Wei Chen Xiangyi Zheng Tobias Achu Muluh Xiaobin Wang Maolin Wang Xing-Sheng Shu

Published in: Cancer research (2024)

ENL plays a key role in decoding epigenetic marks at highly active oncogenic super-enhancers and can be targeted in combination with BET inhibition as a promising synergistic strategy for optimizing cancer treatment.

Keyphrases

transcription factor
cancer therapy
dna methylation
gene expression
poor prognosis
drug delivery
binding protein