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Targeting the Epigenetic Reader ENL Inhibits Super-Enhancer-Driven Oncogenic Transcription and Synergizes with BET Inhibition to Suppress Tumor Progression.

Yongheng ChenYing YingWenlong MaHongchao MaLiang ShiXuefeng GaoMin JiaMeiqi LiXiaoman SongWeixiao KongWei ChenXiangyi ZhengTobias Achu MuluhXiaobin WangMaolin WangXing-Sheng Shu
Published in: Cancer research (2024)
ENL plays a key role in decoding epigenetic marks at highly active oncogenic super-enhancers and can be targeted in combination with BET inhibition as a promising synergistic strategy for optimizing cancer treatment.
Keyphrases
  • transcription factor
  • cancer therapy
  • dna methylation
  • gene expression
  • poor prognosis
  • drug delivery
  • binding protein