Individualized or fixed approach to pulmonary vein isolation utilizing the fourth-generation cryoballoon in patients with paroxysmal atrial fibrillation: the randomized INDI-FREEZE trial.
Christian-Hendrick HeegerSorin Stefan PopescuRoza SaraeiBettina KirsteinSascha HatahetOmar SamaraAnna TraubMarcel FeheGabriele D'AmbrosioAhmad KeelaniMichael SchlüterCharlotte EitelJulia VoglerKarl Heinz KuckRoland Richard TilzPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2022)
Compared to the fixed protocol, the individualized approach provides a similar safety profile and clinical outcome, while reducing the total freezing time.
Keyphrases
- atrial fibrillation
- phase iii
- catheter ablation
- phase ii
- oral anticoagulants
- open label
- left atrial
- left atrial appendage
- double blind
- clinical trial
- direct oral anticoagulants
- placebo controlled
- study protocol
- randomized controlled trial
- heart failure
- percutaneous coronary intervention
- coronary artery disease
- left ventricular
- venous thromboembolism