The Prognostic Value of the New Combined Hemo-Eosinophil Inflammation Index (HEI Index): A Multicenter Analysis of Anal Cancer Patients Treated with Concurrent Chemo-Radiation.
Margherita RiminiPierfrancesco FrancoBerardino De BariMaria Giulia ZampinoStefano VaggeGiovanni Luca FrassinettiFrancesca ArcadipaneAlmalina BacigalupoMartina ValgiustiDeborah AloiLorenzo GervasoRenzo CorvòGiulia BartoliniMarianna Alessandra GerardiStefano CascinuStefano CascinuPublished in: Cancers (2021)
Anal squamous cell carcinoma (SCC) is a rare tumor, and bio-humoral predictors of response to chemo-radiation (CT-RT) are lacking. We developed a prognostic score system based on laboratory inflammation parameters. We investigated the correlation between baseline clinical and laboratory variables and disease-free (DFS) and overall (OS) survival in anal SCC patients treated with CT-RT in five institutions. The bio-humoral parameters of significance were included in a new scoring system, which was tested with other significant variables in a Cox's proportional hazard model. A total of 308 patients was included. We devised a prognostic model by combining baseline hemoglobin level, SII, and eosinophil count: the Hemo-Eosinophils Inflammation (HEI) Index. We stratified patients according to the HEI index into low- and high-risk groups. Median DFS for low-risk patients was not reached, and it was found to be 79.5 months for high-risk cases (Hazard Ratio 3.22; 95% CI: 2.04-5.10; p < 0.0001). Following adjustment for clinical covariates found significant at univariate analysis, multivariate analysis confirmed the HEI index as an independent prognostic factor for DFS and OS. The HEI index was shown to be a prognostic parameter for DFS and OS in anal cancer patients treated with CT-RT. An external validation of the HEI index is mandatory for its use in clinical practice.
Keyphrases
- prognostic factors
- end stage renal disease
- squamous cell carcinoma
- chronic kidney disease
- ejection fraction
- oxidative stress
- newly diagnosed
- computed tomography
- immune response
- clinical practice
- locally advanced
- magnetic resonance imaging
- high grade
- cross sectional
- photodynamic therapy
- contrast enhanced
- peritoneal dialysis
- papillary thyroid
- patient reported outcomes
- high resolution
- positron emission tomography
- peripheral blood
- dual energy
- free survival
- high speed
- squamous cell
- rectal cancer
- data analysis