Genistein ameliorated experimentally induced gastric ulcer in rats via inhibiting gastric tissues fibrosis by modulating Wnt/β-catenin/TGF-β/PKB pathway.

Hanan M HassanNouf M AlatawiAlaa BagalagelReem DiriAhmad NoorDeina AlmasriHussain T BakhshHussam I KutbiNoha AshyMohammed M H Al-Gayyar

Published in: Redox report : communications in free radical research (2023)

Besides antioxidant activity, genistein improves experimentally induced GU in rats, at least in part, via reduction of gastric tissue fibrosis as indicated by reduction in expression of Wnt, β-catenin, TGF-β, SMAD4, and PKB.

Keyphrases

cell proliferation
transforming growth factor
epithelial mesenchymal transition
high glucose
stem cells
diabetic rats
signaling pathway
drug induced
poor prognosis