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Human amnion epithelial cells and their soluble factors reduce liver fibrosis in murine non-alcoholic steatohepatitis.

Nathan KukAlexander HodgeYing SunJeanne CorreiaMajid AlhomraniChrishan SamuelGregory MooreRebecca LimWilliam Sievert
Published in: Journal of gastroenterology and hepatology (2019)
Human amnion epithelial cell and hAEC-CM significantly reduced hepatic inflammation and fibrosis in a diet-induced non-alcoholic fatty liver disease model. Although hAEC and hAEC-CM did not affect the metabolic components of NASH, their therapeutic potential is promising and warrants further investigation.
Keyphrases
  • liver fibrosis
  • endothelial cells
  • pluripotent stem cells
  • oxidative stress