Human amnion epithelial cells and their soluble factors reduce liver fibrosis in murine non-alcoholic steatohepatitis.
Nathan KukAlexander HodgeYing SunJeanne CorreiaMajid AlhomraniChrishan SamuelGregory MooreRebecca LimWilliam SievertPublished in: Journal of gastroenterology and hepatology (2019)
Human amnion epithelial cell and hAEC-CM significantly reduced hepatic inflammation and fibrosis in a diet-induced non-alcoholic fatty liver disease model. Although hAEC and hAEC-CM did not affect the metabolic components of NASH, their therapeutic potential is promising and warrants further investigation.