Alpha-Chymotrypsin Protects Against Acute Lung, Kidney, and Liver Injuries and Increases Survival in CLP-Induced Sepsis in Rats Through Inhibition of TLR4/NF-κB Pathway.
Shaymaa Ramzy SenousyAl-Shaimaa F AhmedDalia A AbdelhafeezMohamed Montaser A KhalifaMohammad A S AbourehabMahmoud El-DalyPublished in: Drug design, development and therapy (2022)
α-ch has protective potential against sepsis through lowering tissue expression of TLR4, NF-κB, MPO, and iNOS leading to decreased oxidative stress and inflammatory signals induced by sepsis. This effect appeared to alleviate the damage to the lungs, liver, and kidneys and increase survival in rats subjected to sepsis.
Keyphrases
- oxidative stress
- septic shock
- acute kidney injury
- intensive care unit
- diabetic rats
- nuclear factor
- signaling pathway
- toll like receptor
- inflammatory response
- immune response
- lps induced
- dna damage
- poor prognosis
- ischemia reperfusion injury
- liver failure
- drug induced
- induced apoptosis
- pi k akt
- long non coding rna
- room temperature
- respiratory failure
- nitric oxide
- cell proliferation
- ionic liquid
- binding protein
- stress induced