Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with REM sleep behavior disorder: A substudy of the North American Prodromal Synucleinopathy Consortium.
Jonathan E ElliottBrittany R LigmanMohini D Bryant-EkstrandAllison T KeilKatherine PowersCosette OlivoLee E NeilsonRonald B PostumaAmélie PelletierJean-François GagnonZiv Gan OrEric YuLang LiuErik K St LouisLeah K ForsbergJulie A FieldsOwen A RossDaniel E HuddlestonDonald L BliwiseAlon Y AvidanMichael J HowellCarlos H SchenckJennifer McLelandSusan R CriswellAleksandar VidenovicEmmanuel H DuringMitchell G MiglisDavid R ShprecherJoyce K Lee-IannottiBradley F BoeveYo-El S JuMiranda M Limnull nullPublished in: Sleep (2024)
This cross-sectional, matched case:control study shows individuals with RBD+NT have significantly worse neurological measures related to common features of an overt synucleinopathy. Confirmatory longitudinal studies are ongoing; however, these results suggest RBD+NT may be associated with more advanced neurological symptoms related to an evolving neurodegenerative process.