Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials.
Konark MalhotraJason J ChangArjun KhungerDavid BlackerJeffrey A SwitzerNitin GoyalAdrian V HernandezVinay PasupuletiAndrei V AlexandrovGeorgios TsivgoulisPublished in: Journal of neurology (2018)
Although data is limited, minocycline demonstrated efficacy and seems a promising neuroprotective agent in acute stroke patients, especially in AIS subgroup. Further RCTs are needed to evaluate the efficacy and safety of minocycline among ICH patients.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- liver failure
- prognostic factors
- peritoneal dialysis
- randomized controlled trial
- drug induced
- intensive care unit
- patient reported outcomes
- study protocol
- data analysis
- combination therapy
- aortic dissection
- cerebral ischemia
- open label