Inhibition of CC chemokine receptor 1 ameliorates osteoarthritis in mouse by activating PPAR-γ.
Hanqing XuSheng ChenCheng MengYi HeXiao-Jian HuangHong-Bo YouPublished in: Molecular medicine (Cambridge, Mass.) (2024)
This study demonstrated the expression of CCR1 in chondrocytes. Inhibiting CCR1 reduced the inflammatory response, alleviated cartilage aging, and retarded degeneration through the MAPK signaling pathway and PPAR-γ, suggesting its potential therapeutic value for OA.
Keyphrases
- signaling pathway
- inflammatory response
- pi k akt
- epithelial mesenchymal transition
- induced apoptosis
- dendritic cells
- regulatory t cells
- insulin resistance
- poor prognosis
- knee osteoarthritis
- extracellular matrix
- lipopolysaccharide induced
- oxidative stress
- lps induced
- immune response
- toll like receptor
- adipose tissue
- cell proliferation