Faecal microbiota transplantation (FMT) with dietary therapy for acute severe ulcerative colitis.
Samuel Paul CostelloAlice DayChu K YaoRobert Venning BryantPublished in: BMJ case reports (2020)
A 19-year-old man presented with acute severe ulcerative colitis. He was taking azathioprine (therapeutic metabolites) and sulphasalazine as well as infliximab with a therapeutic drug level. On day 3 of hydrocortisone therapy, he met day Oxford criteria with >8 bloody stools per day and was given faecal microbiota transplantation and subsequently commenced on dietary therapy combining several strategies-(1) increased intake of fermentable fibres, (2) reduced intake of overall and sulfur-containing protein and (3) restriction of sulfate and sulfite food additives. At week 8 assessment, he was in clinical and endoscopic remission and remained in clinical and endoscopic remission at 12 months.
Keyphrases
- ulcerative colitis
- drug induced
- liver failure
- ultrasound guided
- respiratory failure
- early onset
- cell therapy
- aortic dissection
- randomized controlled trial
- clinical trial
- hepatitis b virus
- rheumatoid arthritis
- ms ms
- disease activity
- intensive care unit
- tyrosine kinase
- stem cells
- physical activity
- small molecule
- human health
- bone marrow
- systemic lupus erythematosus
- body mass index
- climate change
- electronic health record
- adverse drug
- smoking cessation