SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease.
B BaldoS GaberyR Soylu-KucharzR Y CheongJ B HenningsenE EnglundC McLeanD KirikGlenda M HallidayÅsa PetersénPublished in: Neuropathology and applied neurobiology (2018)
We show that SIRT1 expression is increased in HD-affected brain regions and that metabolic pathways are altered in the HD hypothalamus.