Obstructive Sleep Apnea Plasma-Derived Exosomes Mediate Cognitive Impairment Through Hippocampal Neuronal Cell Pyroptosis.
Zhifeng ChenYulin ShangYanru OuChong ShenYing CaoHui HuRuibing YangTing LiuQingqing LiuMin SongDandan ZongXudong XiangYating PengRuoyun OuyangPublished in: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry (2024)
The results of this study show a hypothesis that plasma-derived exosomes from severe OSA patients promote pyroptosis and increased expression of inflammatory factors in vivo and in vitro, and lead to impaired cognitive function in mice, suggesting that OSA-EXOS can mediate CI through pyroptosis of hippocampal neurons. In addition, exosome cargo from OSA-EXOS showed a unique miRNAs profile compared to NC-EXOS, suggesting that plasma exosome associated miRNAs may reflect the differential profile of OSA related diseases, such as CI.
Keyphrases
- obstructive sleep apnea
- positive airway pressure
- nlrp inflammasome
- cognitive impairment
- end stage renal disease
- mesenchymal stem cells
- sleep apnea
- stem cells
- newly diagnosed
- cerebral ischemia
- chronic kidney disease
- poor prognosis
- peritoneal dialysis
- prognostic factors
- spinal cord
- single cell
- type diabetes
- bone marrow
- drug induced
- metabolic syndrome