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A common variant in the hepatobiliary phospholipid transporter ABCB4 modulates liver injury in PBC but not in PSC: prospective analysis in 867 patients.

Beata KrukMalgorzata MilkiewiczJoanna Raszeja-WyszomirskaPiotr MilkiewiczMarcin Krawczyk
Published in: Orphanet journal of rare diseases (2022)
The frequent pro-cholestatic variant ABCB4 c.711A > T modulates liver injury in PBC, but not in PSC. In particular, carriers of the major allele are at increased risk of progressive liver scarring.
Keyphrases
  • liver injury
  • drug induced
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • multiple sclerosis
  • peritoneal dialysis
  • fatty acid
  • anti inflammatory