A common variant in the hepatobiliary phospholipid transporter ABCB4 modulates liver injury in PBC but not in PSC: prospective analysis in 867 patients.
Beata KrukMalgorzata MilkiewiczJoanna Raszeja-WyszomirskaPiotr MilkiewiczMarcin KrawczykPublished in: Orphanet journal of rare diseases (2022)
The frequent pro-cholestatic variant ABCB4 c.711A > T modulates liver injury in PBC, but not in PSC. In particular, carriers of the major allele are at increased risk of progressive liver scarring.