CuS@TA-Fe NPs Doped Multifunctional Hydrogel with Peroxide-Like Properties And Photothermal Properties for Synergistic Antimicrobial Repair of Infected Wounds.

Bacterial infection is a critical factor in wound healing. Due to the abuse of antibiotics, some pathogenic bacteria have developed resistance. Thus, there is an urgent need to develop a non-antibiotic-dependent multifunctional wound dressing for the treatment of bacteria-infected wounds. In this work, we prepared multifunctional AOCuT hydrogel embedded with CuS@TA-Fe NPs through Schiff base reaction between gelatin quaternary ammonium salt - gallic acid (O-Gel-Ga) and sodium dialdehyde alginate (ADA) as along with electrostatic interactions with CuS@TA-Fe NPs. These composite hydrogels possess favorable injectability, rapid shape adaptation, electrical conductivity, photothermal antimicrobial activity, and biocompatibility. Additionally, the doped NPs not only imparted fast self-healing properties and excellent adhesion performance to the hydrogels, but also provided excellent peroxide-like properties, enabling then to scavenge free radicals and exhibit anti-inflammatory and antioxidant capabilities via photothermal (PTT) and photodynamic (PDT) effects. In an S. aureus infected wound model, the composite hydrogel effectively reduced the expression level of wound inflammatory factors and accelerated collagen deposition, epithelial tissue and vascular regeneration, thereby promoting wound healing. This safe and synergistic therapeutic system holds great promise for clinical applications in the treatment of infectious wounds. This article is protected by copyright. All rights reserved.