Proton Pump Inhibitors and Cyclin-Dependent Kinase 4/6 Inhibitors in Patients With Breast Cancer.

Kaori TakahashiRyuji UozumiToru MukoharaTetsu HayashidaMidori IwabeHirotoshi IiharaKanako Kusuhara-MamishinYuko KitagawaMasami TsuchiyaMika KitahoraAiko NagayamaShinkichi KosakaYoshimi Asano-NiwaTomoko SekiKoji OhnukiAkio SuzukiFumiko OnoManabu FutamuraHitoshi KawazoeTomonori Nakamura

Published in: The oncologist (2024)

The effectiveness of cyclin-dependent kinase 4/6 inhibitors is unlikely to be affected by concomitant PPI use. Future prospective pharmacokinetic studies are warranted.

Keyphrases

cell cycle
randomized controlled trial
systematic review
current status
protein protein
cell proliferation
signaling pathway