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Quercetin Regulates Key Components of the Cellular Microenvironment during Early Hepatocarcinogenesis.

Itayetzi Reyes-AvendañoEdilburga Reyes-JiménezKarina González-GarcíaDulce Carolina Pérez-FigueroaRafael Baltiérrez-HoyosGabriela Tapia-PastranaXariss Miryam Sánchez-ChinoSaúl Villa-TreviñoJaime Arellanes-RobledoVerónica Rocío Vásquez-Garzón
Published in: Antioxidants (Basel, Switzerland) (2022)
Hepatocellular carcinoma (HCC) is a health problem worldwide due to its high mortality rate, and the tumor microenvironment (TME) plays a key role in the HCC progression. The current ineffective therapies to fight the disease still warrant the development of preventive strategies. Quercetin has been shown to have different antitumor activities; however, its effect on TME components in preneoplastic lesions has not been fully investigated yet. Here, we aimed to evaluate the effect of quercetin (10 mg/kg) on TME components during the early stages of HCC progression induced in the rat. Histopathological and immunohistochemical analyses showed that quercetin decreases the size of preneoplastic lesions, glycogen and collagen accumulation, the expression of cancer stem cells and myofibroblasts markers, and that of the transporter ATP binding cassette subfamily C member 3 (ABCC3), a marker of HCC progression and multi-drug resistance. Our results strongly suggest that quercetin has the capability to reduce key components of TME, as well as the expression of ABCC3. Thus, quercetin can be an alternative treatment for inhibiting the growth of early HCC tumors.
Keyphrases
  • poor prognosis
  • cancer stem cells
  • healthcare
  • stem cells
  • public health
  • oxidative stress
  • mental health
  • high glucose
  • long non coding rna
  • climate change
  • social media
  • diabetic rats
  • high resolution
  • drug induced