H. pylori modulates DC functions via T4SS/TNFα/p38-dependent SOCS3 expression.
Muamera SarajlicTheresa NeuperJulia VetterSusanne SchallerMaria M KlicznikIris K GratzSilja WesslerGernot PosseltJutta Horejs-HoeckPublished in: Cell communication and signaling : CCS (2020)
This study shows that H. pylori induces SOCS3 via an autocrine loop involving the T4SS and TNFα and p38 signaling. Moreover, we demonstrate that high levels of SOCS3 in DCs dampen PD-L1 expression on DCs, which in turn drives T-cell proliferation. Video Abstract.