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VhH anti-thrombomodulin clone 1 inhibits TAFI activation and enhances fibrinolysis in human whole blood under flow.

Marc V A van MoorselGeke C PoolenCornelis A KoekmanSandra VerhoefSteven de MaatArjan BarendrechtNadine D van KleefJoost C M MeijersRaymond M SchiffelersCoen MaasRolf T Urbanus
Published in: Journal of thrombosis and haemostasis : JTH (2022)
We have developed VhH anti-TM clone 1, which inhibits TAFI activation and enhances tPA-mediated fibrinolysis under flow. Different from agents that directly target TAFIa, our strategy should preserve direct TAFI activation via thrombin.
Keyphrases
  • endothelial cells
  • pluripotent stem cells