Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.
Valgerdur SteinthorsdottirRalph McGinnisNicholas O WilliamsLilja StefansdottirGudmar ThorleifssonScott ShooterJoão FadistaJon K SigurdssonKirsi M AuroGalina BerezinaMaria-Carolina BorgesSuzannah BumpsteadJonas Byberg-GrauholmIrina ColgiuVivien A DolbyFrank DudbridgeStephanie M EngelChristopher S FranklinMichael L FriggeYr FrisbaekReynir T GeirssonFrank GellerSolveig GretarsdottirDaníel F GuðbjartssonQuaker HarmonDavid Michael HougaardTatyana HegayAnna HelgadottirSigrun HjartardottirTiina J JääskeläinenHrefna JohannsdottirIngileif JónsdóttirThorhildur JuliusdottirNoor KalshekerAbdumadjit KasimovJohn P KempKatja KivinenKari KlungsøyrWai K LeeMads MelbyeZosia MiedzybrodskaAshley MoffettDilbar NajmutdinovaFiruza NishanovaThorunn OlafsdottirMarkus PerolaFiona Broughton PipkinLucilla PostonGordon PrescottSaedis SaevarsdottirDamilya SalimbayevaPaula Juliet ScaifeLine SkotteEleonora Staines-UriasOlafur Andri StefanssonKarina Meden SørensenLiv Cecilie Vestrheim ThomsenVinicius TraganteLill TrogstadNigel A B Simpsonnull nullnull nullTamara AripovaJuan P CasasAnna F DominiczakJames J WalkerUnnur ThorsteinsdottirAnn-Charlotte IversenBjarke FeenstraDeborah A LawlorHeather Allison BoydPer MagnusFinnpec Hannele LaivuoriNodira ZakhidovaGulnara SvyatovaKári StefánssonLinda MorganPublished in: Nature communications (2020)
Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Keyphrases
- pregnancy outcomes
- blood pressure
- pregnant women
- early onset
- copy number
- body mass index
- systematic review
- weight gain
- genome wide
- birth weight
- healthcare
- hypertensive patients
- public health
- genome wide association
- heart rate
- physical activity
- randomized controlled trial
- blood glucose
- risk assessment
- gene expression
- preterm birth
- dna methylation
- skeletal muscle
- meta analyses
- insulin resistance
- glycemic control
- human health