In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry.

Liora Bik Martijn Bastiaan Adriaan van Doorn Anders C N Hansen Christian Janfelt Uffe Hoegh Olesen Merete Haedersdal Catharina Margrethe Lerche Kristoffer K Hendel

Published in: Expert opinion on drug delivery (2022)

BLM administered by EPI resulted in quantifiable and focal mid-dermal distribution of BLM. The high skin bioavailability holds a great potential for clinical effects and warrants further evaluation in future human studies.

Keyphrases

mass spectrometry
wound healing
endothelial cells
liquid chromatography
induced pluripotent stem cells
current status
pluripotent stem cells
pulmonary fibrosis
soft tissue
high performance liquid chromatography
capillary electrophoresis
case control
emergency department
drug induced
ms ms
tandem mass spectrometry