PET Imaging of Self-Assembled 18 F-Labelled Pd 2 L 4 Metallacages for Anticancer Drug Delivery.

Raúl CosiallsCristina SimóSalvador BorrósVanessa Gómez-VallejoClaudia Schmidt Jordi Llop Ana Belén Cuenca Angela Casini

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2022)

To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18 F-labelled [Pd 2 L 4 ] 4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

Keyphrases

pet imaging
pet ct
positron emission tomography
drug delivery
mass spectrometry
high resolution
molecular docking
computed tomography
multiple sclerosis
fluorescence imaging
photodynamic therapy
high fat diet induced
ms ms
liquid chromatography
metabolic syndrome
type diabetes
insulin resistance
iron oxide