Benefits and risks of clofarabine in adult acute lymphoblastic leukemia investigated in depth by multi-state modeling.
Sjoerd J F HermansYvette van NordenJurjen VersluisAnita W RijneveldBronno van der HoltOkke de WeerdtBart J BiemondArjan A van de LoosdrechtLotte E van der WagenMar BellidoMichel van GelderWalter J F M van der VeldenDominik SelleslagDaniëlle van Lammeren-VenemaVincent H J van der VeldenLiesbeth C de WreedeDouwe PostmusFrancesco PignattiJan J CornelissenPublished in: Cancer medicine (2024)
We conclude that the intermediate states, i.e., going off-protocol and MRD-negativity, were affected by adding CLO, but these transitions were not associated with subsequent survival estimates, suggesting relatively modest antileukemic activity in ALL.