Transcriptomic heterogeneity of EGFR-mutant non-small cell lung cancer evolution towards small cell lung cancer.
Songji OhJaemoon KohTae Min KimSoyeon KimJeonghwan YoukMiso KimBhumsuk KeamYoon Kyung JeonJa-Lok KuDong Wan KimDoo Hyun ChungDae Seog HeoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Our study demonstrated most t-SCLC showed neuronal subtypes with low EGFR expression. DEGs analysis and t-SCLC preclinical models identified an epigenetic modifier as a promising treatment strategy for t-SCLC.