YAP-galectin-3 signaling mediates endothelial dysfunction in angiotensin II-induced hypertension in mice.
Zheng-Da PangXia SunRu-Yue BaiMeng-Zhuan HanYong-Jian ZhangWei WuYu ZhangBao-Chang LaiYi ZhangYan WangXiao-Jun DuXiu-Ling DengPublished in: Cellular and molecular life sciences : CMLS (2023)
Our results demonstrate for the first time that Ang II upregulates Gal-3 expression via increment in YAP nuclear localization in vascular endothelium, and that Gal-3 mediates endothelial dysfunction contributing to the development of hypertension.
Keyphrases
- angiotensin ii
- blood pressure
- angiotensin converting enzyme
- vascular smooth muscle cells
- poor prognosis
- nitric oxide
- high glucose
- diabetic rats
- high fat diet induced
- drug induced
- binding protein
- type diabetes
- adipose tissue
- oxidative stress
- skeletal muscle
- endothelial cells
- wild type
- insulin resistance
- stress induced