Endoscopic lesions of postoperative anastomotic area in patients with Crohn's disease in the biologic era: A Japanese multi-center nationwide cohort study.

Frequent anastomotic lesions were observed at the postoperative index ileocolonoscopy. These gradually increased for subsequent ileocolonoscopy, even in the biologic era. Regarding lesions on the anastomotic line, intermediate lesions on the anastomotic line (e.g., irregular or deep ulcers) might be considered recurrent disease, and mild lesions (e.g., linear superficial ulcers) might be considered non-recurrent disease. Prospective studies are needed to resolve this issue, including treatment enhancement.