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Interrater agreement of two adverse drug reaction causality assessment methods: A randomised comparison of the Liverpool Adverse Drug Reaction Causality Assessment Tool and the World Health Organization-Uppsala Monitoring Centre system.

Johannes P MoutonUshma MehtaDawn P RossiterGary MaartensKaren Cohen
Published in: PloS one (2017)
We were unable to replicate the high interrater agreement achieved by the LCAT developers and instead found its interrater agreement to be lower than that achieved when using the WHO-UMC system. We identified potential reasons for this and recommend priority areas for improving the LCAT.
Keyphrases
  • adverse drug
  • electronic health record
  • emergency department
  • clinical trial
  • drug induced
  • open label
  • study protocol
  • randomized controlled trial
  • double blind
  • electron transfer