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Double arcsine transform not appropriate for meta-analysis.

Christian RöverTim Friede
Published in: Research synthesis methods (2022)
The variance-stabilizing Freeman-Tukey double arcsine transform was originally proposed for inference on single proportions. Subsequently, its use has been suggested in the context of meta-analysis of proportions. While some erratic behavior has been observed previously, here we point out and illustrate general issues of monotonicity and invertibility that make this transform unsuitable for meta-analysis purposes.
Keyphrases
  • systematic review
  • meta analyses
  • single cell