Placebo response in pharmacological trials in patients with functional dyspepsia-A systematic review and meta-analysis.
Michelle H M A BosmanFabiënne G M SmeetsSigrid ElsenbruchJan TackMagnus SimrénNicholas J TalleyBjorn WinkensAd MascleeDaniel KeszthelyiPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2022)
The pooled placebo response rate in pharmacological trials in FD is about 39%, depending on which responder definitions is used. Future trials should consider applying an entry criterion based on minimal level of symptom severity to decrease the placebo response. We also suggest separate reporting of core FD symptoms pending more concrete harmonization efforts in FD trials.