Molecular connections of obesity and aging: a focus on adipose protein 53 and retinoblastoma protein.
Dinh-Toi ChuYang TaoPublished in: Biogerontology (2017)
Obesity is an induced health problem that human beings have been facing with non-optimal treatment so far. Humans are on average getting fatter with age, and obesity and aging interact each other to shorten lifetime and decrease life quality. Obesity also causes several aging related-disorders such as cancer, strokes, cardiovascular disease, high blood pressure and type 2 diabetes. So, the molecular connections between aging and obesity are promising targets for bio-medical researches and innovative therapies of many health problems. In this review, we discuss the findings of adipose p53 and Rb-two central molecular linkages between aging and obesity-on lipid metabolism and obesity.
Keyphrases
- insulin resistance
- type diabetes
- metabolic syndrome
- weight loss
- high fat diet induced
- cardiovascular disease
- weight gain
- blood pressure
- healthcare
- adipose tissue
- mental health
- public health
- skeletal muscle
- endothelial cells
- glycemic control
- single molecule
- combination therapy
- stress induced
- cardiovascular risk factors
- social media
- high glucose
- induced pluripotent stem cells
- health promotion
- smoking cessation
- hypertensive patients
- pluripotent stem cells