Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancer.
Susana RamalhoLiliana Al De Angelo AndradeCássio Cardoso FilhoRodrigo de Andrade NatalMarina PavanelloAmanda Canato FerraciniLuis Felipe SallumLuis Otávio SarianSophie DerchainPublished in: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (2019)
The objective of this study is to evaluate the relationship between discoidin domain receptor 2 (DDR2) and miR-182 expression with response to platinum-based chemotherapy and survival in women with high-grade serous ovarian cancer (HGSOC). We evaluated 78 women with HGSOC stages I-IV, diagnosed between 1996 and 2013, and followed up until 2016. DDR2 expression was assessed using immunohistochemistry on tissue microarray slides. The microRNAs were evaluated by qRT-PCR. DDR2 expression was high in 11 (14.1%) women. PFS was significantly lower in women with FIGO stage I/II - versus III/IV, post-surgery residual disease and high expression of DDR2. Women with postsurgery residual disease, FIGO stage I/II - versus III/IV and DDR2 expression had worse OS, but only post-surgery residual disease remained an independent prognostic factor for worse OS in multivariable analysis. miR-182 expression levels were significantly lower in patients harboring tumors with higher expression of DDR2 (p < 0.001). In this relatively large cohort of women with HSGOC, higher DDR2 expression was associated with lower miR-182 levels and worse PFS, suggesting that these molecules may be associated with mechanisms of HGSOC progression.
Keyphrases
- poor prognosis
- high grade
- long non coding rna
- binding protein
- cell proliferation
- prognostic factors
- end stage renal disease
- minimally invasive
- chronic kidney disease
- type diabetes
- metabolic syndrome
- peritoneal dialysis
- newly diagnosed
- coronary artery disease
- locally advanced
- polycystic ovary syndrome
- coronary artery bypass
- rectal cancer
- surgical site infection