High-Salt Diet Inhibits the Expression of Bmal1 and Promotes Atrial Fibrosis and Vulnerability to Atrial Fibrillation in Dahl Salt-Sensitive Rats.
Xiu-Heng WangZhi-Zhu ZhangYun OuZhi-Hong NingJia-Yang YangHong HuangHui-Fang TangZhi-Sheng JiangHeng-Jing HuPublished in: American journal of hypertension (2024)
We demonstrated that a high-salt diet leads to circadian changes in hypertension due to a reduction of Bmal1 expression, which plays a crucial role in atrial fibrosis and increased susceptibility to AF in SSHT rats.
Keyphrases
- atrial fibrillation
- poor prognosis
- left atrial
- catheter ablation
- oral anticoagulants
- weight loss
- physical activity
- left atrial appendage
- direct oral anticoagulants
- blood pressure
- heart failure
- climate change
- percutaneous coronary intervention
- long non coding rna
- binding protein
- left ventricular
- mitral valve
- coronary artery disease
- venous thromboembolism
- liver fibrosis