MicroRNA-101-3p Suppresses mTOR and Causes Mitochondrial Fragmentation and Cell Degeneration in COPD.

Lei FangXinggang WangMing ZhangPetra KhanMichael TammMichael Roth

Published in: Canadian respiratory journal (2022)

Constitutive high miR-101-3p expression characterizes COPD-ASMC, causing increased mitochondrial fragmentation and ASMC deterioration. Thus, reactivation mTOR or blocking miR-101-3p presents a potential new strategy for COPD therapy.

Keyphrases

chronic obstructive pulmonary disease
lung function
oxidative stress
cell proliferation
poor prognosis
single cell
signaling pathway
air pollution
human health
replacement therapy