Impact of Propofol Exposure on Neurocognitive Outcomes in Children With High-Risk B ALL: A Children's Oncology Group Study.
Sarah AlexanderJohn A KairallaSumit GuptaEmily HibbittsHannah WeismanDoralina L AnghelescuNaomi J WinickKevin R KrullWanda L SalzerMichael J BurkeLia GoreMeenakshi DevidasLeanne EmbryElizabeth A RaetzStephen P HungerMignon L LohKristina K HardyPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
In a multicenter and uniformly treated cohort of children with B-ALL, cumulative exposure to propofol was an independent risk factor for impairment in reaction time/processing speed 1 year after therapy. Anesthesia exposure is a modifiable risk, and opportunities to minimize propofol use should be considered.