Cardiorespiratory fitness and free-living physical activity are not associated with cognition in persons with progressive multiple sclerosis: Baseline analyses from the CogEx study.
Brian M SandroffRobert W MotlMaria Pia AmatoGiampaolo BrichettoJeremy ChatawayNancy D ChiaravallotiGary R CutterUlrik DalgasJohn DeLucaRachel FarrellPeter FeysMassimo FilippiJennifer FreemanMatilde IngleseCecilia MezaMaria Assunta RoccaSalter AmberAnthony FeinsteinPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2021)
Cardiorespiratory fitness and MVPA were not associated with cognition in this large progressive MS sample, yet these outcomes represent critical manipulation checks for documenting the success of the CogEx trial. This highlights the importance of examining other exercise-related mechanisms-of-action for improving cognition in progressive MS.