VEGF-R2/CAV-1 Interaction Induced by Resveratrol/Eicosapentaenoic Acid/Docosahexaenoic Acid-Enriched Formulation through Functional Detergent-Resistant Membranes Is Associated with Decreased VEGF-A Release in ARPE-19 Cells.

Maude PerusFlavie CourtautJean-Paul Pais de BarrosVirginie AiresFrançois Hermetet Dominique Delmas

Published in: Molecular nutrition & food research (2024)

This specific interaction can provide a new strategy for countering VEGF-A production in human RPE cells and, consequently, reducing neovascularization in AMD. Further preclinical studies involving O3FAs and polyphenols are warranted.

Keyphrases

endothelial cells
vascular endothelial growth factor
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
signaling pathway
bone marrow
pi k akt
pluripotent stem cells