Characterization of two rat models of cystic fibrosis-KO and F508del CFTR-Generated by Crispr-Cas9.
Elise DreanoMarc BacchettaJuliette SimoninLouise GalmicheClaire UsalLotfi SlimaniJérémy SadoineLaurent TessonIgnacio AnegonJean-Paul ConcordetAurélie HattonLucile VignaudDanielle TondelierIsabelle Sermet-GaudelusMarc ChansonCharles-Henry CottartPublished in: Animal models and experimental medicine (2019)
The F508del rats reproduce the phenotypes observed in CFTR KO animals and represent a novel resource to advance the development of CF therapeutics.