Impact of adequate empirical combination therapy on mortality in septic shock due to Pseudomonas aeruginosa bloodstream infections: a multicentre retrospective cohort study.
Antonio VenaMichela SchenoneSilvia CorcioneMaddalena GiannellaRenato PascaleDaniele Roberto GiacobbeMarco MuccioSimone Mornese PinnaBianca PariFrancesca GiovannenzeNicholas GeremiaMalgorzata MikulskaEleonora TaddeiFlavio SangiorgiDavide Fiore BavaroVincenzo ScaglioneVeronica VassiaMarco MerliMichele BartolettiPierluigi VialeFrancesco Giuseppe De RosaMatteo Bassettinull nullPublished in: The Journal of antimicrobial chemotherapy (2024)
AECT may be associated with reduced mortality compared to monotherapy in septic shock patients due to P. aeruginosa BSI. However, the administration of definitive adequate monotherapy or combination therapy yields similar outcomes, suggesting that once susceptibility is documented, switching to a single active in vitro drug is safe and feasible. Further studies are recommended to validate these findings.
Keyphrases
- combination therapy
- septic shock
- pseudomonas aeruginosa
- end stage renal disease
- cardiovascular events
- ejection fraction
- newly diagnosed
- chronic kidney disease
- cystic fibrosis
- risk factors
- clinical trial
- peritoneal dialysis
- prognostic factors
- study protocol
- emergency department
- patient reported outcomes
- metabolic syndrome
- cross sectional
- biofilm formation
- case control
- insulin resistance
- open label