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Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture.

Jennifer R S MeadowsJeffrey M KiddGuo-Dong WangHeidi G ParkerPeter Z SchallMatteo BianchiMatthew J ChristmasKatia BougiouriReuben M BuckleyChristophe HitteAnthony K NguyenChao WangVidhya JagannathanJulia E NiskanenLaurent Alain François FrantzMeharji ArumilliSruthi HundiKerstin Lindblad-TohCatarina GinjaKadek Karang AgustinaCatherine AndréAdam R BoykoBrian W DavisMichaela DrögemüllerXin-Yao FengKonstantinos GkagkavouzisGiorgos IliopoulosAlexander C HarrisMarjo K HytönenDaniela C KalthoffYan-Hu LiuPetros LymberakisNikolaos PoulakakisAna Elisabete PiresFernando RacimoFabian Ramos-AlmodovarPeter SavolainenSemina VenetsaniImke TammenAlexandros TriantafyllidisBridgett M vonHoldtRobert K WayneGreger LarsonFrank W NicholasHannes T LohiTosso LeebYa-Ping ZhangElaine A Ostrander
Published in: Genome biology (2023)
We have developed a dense dataset of 1987 sequenced canids that reveals patterns of allele sharing, identifies likely functional variants, informs breed structure, and enables accurate imputation. Dog10K data are publicly available.
Keyphrases
  • genome wide
  • copy number
  • dna methylation
  • electronic health record
  • single cell
  • social media
  • high resolution
  • health information
  • big data
  • healthcare
  • gene expression
  • machine learning