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Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project.

Carolin MoessnangSarah BaumeisterJulian TillmannDavid GoyardTony CharmanSara AmbrosinoSimon Baron-CohenChristian BeckmannSven BölteCarsten BoursDaisy CrawleyFlavio Dell'AcquaSarah DurstonChristine EckerVincent FrouinHannah HaywardRosemary HoltMark JohnsonEmily JonesMeng-Chuan LaiMichael V LombardoLuke MasonMarianne OldenhinkelAntonio PersicoAntonia San José CáceresWill SpoorenEva LothDeclan G M MurphyJan K BuitelaarTobias BanaschewskiDaniel BrandeisHeike TostAndreas Meyer-Lindenbergnull null
Published in: Molecular autism (2020)
Contrary to prior reports, this large-scale study does not support the assumption that altered social brain activation during mentalizing forms a common neural marker of ASD, at least with the paradigm we employed. Yet, autistic individuals show socio-behavioral deficits. Our work therefore highlights the need to interrogate social brain function with other brain measures, such as connectivity and network-based approaches, using other paradigms, or applying complementary analysis approaches to assess individual differences in this heterogeneous condition.
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