Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors.

Hui LiuMohammad DehestaniCornelis BlauwendraatMary B MakariousHampton LeonardJonggeol J KimClaudia SchulteAlastair J NoyceBenjamin M JacobsIsabelle Francesca Foote Manu Sharmanull nullMike NallsAndrew SingletonThomas GasserSara Bandres-Ciga

Published in: Annals of neurology (2022)

The present study represents a novel and comprehensive assessment of heritable genetic variation contributing to PD resistance. We show that a genetic resilience score can modify the penetrance of PD genetic risk factors and therefore protect individuals carrying a high-risk genetic burden from developing PD. ANN NEUROL 2022;92:270-278.

Keyphrases

risk factors
parkinson disease
genome wide
copy number
climate change
deep brain stimulation
social support
gene expression