GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome.
Zhangjin QinJiaqi SongAolei LinWei YangWenbo ZhangFuxin ZhongLihong HuangYang LüWeihua YuPublished in: Journal of neuroinflammation (2022)
GPR120 modulates epileptic seizure activity and affects neuronal survival in KA-induced mouse model of temporal lobe epilepsy. Furthermore, GPR120 regulated neuroinflammation in epileptic animals through NLRP3/Caspase-1/IL-1β signaling pathway.
Keyphrases
- temporal lobe epilepsy
- nlrp inflammasome
- mouse model
- fatty acid
- signaling pathway
- cerebral ischemia
- traumatic brain injury
- lipopolysaccharide induced
- lps induced
- induced apoptosis
- cognitive impairment
- cell death
- high glucose
- diabetic rats
- transcription factor
- epithelial mesenchymal transition
- drug induced
- blood brain barrier
- subarachnoid hemorrhage
- brain injury