The Beneficial Effects of Apical Sodium-Dependent Bile Acid Transporter Inactivation Depend on Dietary Fat Composition.

Ivo P Van de PeppelAnuradha RaoMarleen B DommerholtLaura BongiovanniRachel ThomasAlain de BruinSaul J KarpenPaul A DawsonHenkjan J VerkadeJohan W Jonker

Published in: Molecular nutrition & food research (2020)

The beneficial metabolic effects of ASBT inactivation on diet-induced obesity depend on decreased intestinal absorption of SFAs, and thus on the dietary fatty acid composition. These findings highlight the importance of dietary fatty acid composition in the therapeutic effects of ASBT inhibition.

Keyphrases

fatty acid
metabolic syndrome
insulin resistance
type diabetes
adipose tissue
weight loss
body mass index
high fat diet induced
physical activity