Hepatocyte KLF6 expression affects FXR signalling and the clinical course of primary sclerosing cholangitis.

Svenja Sydor Paul MankaLea van BurenSarah TheurerSuzan SchwertheimJan BestJanette HeegsmaAli SaeedDiana VetterMartin SchlattjanAnna DittrichMaria I FielHideo A BabaAlexander DechêneFrancisco J CuberoGuido GerkenPeter LemmerHan MoshageScott L FriedmanKlaas Nico FaberLars P Bechmann

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

Here, we show an association between KLF6 expression and the clinical course and overall survival in PSC patients. Mechanistically, we identified a direct interaction of KLF6 with the FXR target gene NR0B2.

Keyphrases

poor prognosis
end stage renal disease
transcription factor
ejection fraction
newly diagnosed
peritoneal dialysis
binding protein
long non coding rna
liver injury
patient reported outcomes
drug induced
patient reported
free survival