Tenascin-C as a potential marker for immunohistopathology of doxorubicin-induced cardiomyopathy.

Tatsuya Nishikawa Mikio ShibaYoshihiko IkedaKeiko Ohta-OgoTakumi KondoTomoka TabataToru OkaWataru ShioyamaHironori YamamotoTaku YasuiYoshiharu HiguchiHatsue Ishibashi-UedaKeiichiro HonmaChisato IzumiShuichiro Higo Kinta Hatyakeyama Yasushi SakataMasashi Fujita

Published in: European heart journal open (2023)

The combined histopathological assessment for tenascin-C, macrophages, and p62/ubiquitin may serve as a novel tool for the diagnosis of DOX-CM. Doxorubicin may directly affect the expression of tenascin-C in the myocardium.

Keyphrases

drug delivery
poor prognosis
cancer therapy
high glucose
heart failure
diabetic rats
small molecule
drug induced
binding protein
oxidative stress
climate change