Bmi-1-induced miR-27a and miR-155 promote tumor metastasis and chemoresistance by targeting RKIP in gastric cancer.

Yaqing LiZhenfeng TianYing TanGuoda LianShangxiang ChenShaojie ChenJiajia LiXuanna LiKaihong HuangYinting Chen

Published in: Molecular cancer (2020)

Bmi-1 was proven to induce the expression of miR-27a and miR-155 and thus promote tumor metastasis and chemoresistance by targeting RKIP in GC. Overall, miR-27a and miR-155 might be promising targets for the screening, diagnosis, prognosis, treatment and disease monitoring of GC.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
poor prognosis
body mass index
mass spectrometry
combination therapy
simultaneous determination