Visuo-spatial processing is linked to cortical glutamate dynamics in Parkinson's disease - a 7 Tesla functional MRS study.

Our results indicate that functional MRS captures even subtle differences in neural processing linked to the behavioral performance, missed by conventional, static MRS. Functional MRS, thus, represents a promising tool for studying molecular alterations at high sensitivity. Its prognostic potential should be evaluated in longitudinal studies, prospectively contributing to earlier diagnosis and individual treatment decisions.