Expression of upstream and downstream targets of mTOR pathway in seven cases of secretory carcinoma of salivary gland origin.

Marcos CustódioBruno Tavares SedassariAlbina AltemaniMaria Fernanda Setúbal Destro RodriguesFábio Daumas NunesSuzana Cantanhede Orsini Machado de Sousa

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2020)

SCsg shows different expression patterns for the mTOR signalling molecules, but only eIF4E was highly expressed. This may suggest alternative signalling pathways other than Akt and mTOR in this group of tumours.

Keyphrases

cell proliferation
poor prognosis
binding protein
signaling pathway
long non coding rna