Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis.
Alejandro Prieto-CastañedaFernando García-GarridoCarolina Díaz-NorambuenaBlanca Escriche-NavarroAlba García-FernándezJorge BañuelosEsther RebollarInmaculada García-MorenoRamón Martínez-MáñezSantiago de la MoyaAntonia R AgarrabeitiaMaria J OrtizPublished in: Organic letters (2022)
We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY-BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.