Upregulation of HMGB1 in tumor-associated macrophages induced by tumor cell-derived lactate further promotes colorectal cancer progression.

Xinyi GaoShiqi ZhouZhaofu QinDechuan LiYuping ZhuDe-Ning Ma

Published in: Journal of translational medicine (2023)

The lactate metabolized by cancer cells stimulated M2 polarization and HMGB1 secretion by macrophages, aggravating the carcinogenic behaviors of cancer cells.

Keyphrases

poor prognosis
cell proliferation
signaling pathway
long non coding rna